"...a faster, funnier follow-up (to the 2001 original)..."
— Joe Leydon, Variety"It's a critter movie gone mad with gravity-defying animals, all sorts of gizmos and no doubt a few stunts that didn't require CGI — but who can tell which ones? For every gag that works — a cat mixing up his pet mouse and computer mouse — many, many more fail."
— Kirk Honeycutt, Hollywood Reporter"...deliver(s) every pet-related groaner imaginable within 85 minutes."
— Michelle Orange, Village Voice"No movie — whether aimed at adults or kids or canines themselves — has the right to be as tiresome and unoriginal as this action-comedy mutt."
— Adam Markovitz, Entertainment Weekly"Aimed squarely at a single digital IQ demographic and as irritating as a case of fleas, Cats & Dogs: The Revenge of Kitty Galore stands as just the latest, lamest example of the 'sequel nobody asked for' syndrome that frequently infects Hollywood like mange."
— Bill Gibron, filmcritic.com"...a thoroughly ill-conceived CGI orgy..."
— Simon Abrams, Slant Magazine