| Title | Weekend | Total | Analysis |
| Inception | $27.5M | $193.3M | Powered by repeat viewings, a winner for 3rd straight week and already 7th biggest box office hit of 2010. |
| Dinner for Schmucks | $23.3M | $23.3M | Only so-so reviews contribute to soft opening for this Carell-Rudd comedy. |
| Salt | $19.2M | $70.8M | Modest Week 2 drop-off for fun Angelina Jolie thriller. |
| Despicable Me | $15.5M | $190.3M | Still solidly in the Top 5 in 4th week. |
| Cats & Dogs: The Revenge of Kitty Galore | $12.5M | $12.5M | Insert cat and/or dog pun here. How about, "this movie was spayed and neutered!" |