He’s taken what, on paper, boils down to an extra ridiculous episode of “Law and Order: Criminal Intent” and passes it off as high cinematic art.
—Jordan Hoffman Film.com
Imagine music for a sorcery-related plot and then dial it down to ominous forebodings. Without Thomas Newman's score, Side Effects would be a lesser film, even another film.
—Roger Ebert Chicago Sun Times
Steven Soderbergh's elegantly coiled puzzler spins a tale of clinical depression and psychiatric malpractice into an absorbing, cunningly unpredictable entertainment that, like much of his recent work, closely observes how a particular subset of American society operates in a needy, greedy, paranoid and duplicitous age.
—Justin Chang Variety
Steven Soderbergh, rightly considered one of Hollywood’s smartest movie makers, is at his cleverest in Side Effects, a canny, cunning big idea thriller in a minor key, an engrossing zeitgeist whodunit about Wall Street, Big Pharma, prescription drugs and the power we give psychiatry and psychologists.
—Roger Moore Movie Nation
Like a gel cap in a sip of orange juice, the psycho-pharmacological thriller Side Effects goes down easily, even if its long-term impact turns out to be barely discernible.
—Ann Hornaday Washington Post